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All about Pyrrole disorder with Monica

What is Pyrrole disorder ?

Pyrrole disorder is a condition affecting 1 in 10 people. It refers to an overproduction of pyrroles or hydroxyhaemopyrrolin-2-one (HPL), which is a byproduct of abnormal synthesis and metabolism of haemoglobin which is contained within blood cells (McGinnis et al., 2008).

Elevated HPL levels, inhibit absorption of certain nutrients such as zinc and vitamin B6. This can result in many different disruptions throughout the body in particular to mental health. HPL is also a marker for oxidative stress, and is increased under emotional stress (McGinnis et al., 2008).

Signs and symptoms

Sign & symptoms may present as some of the following;

-Low morning appetite

-Pale skin

-White spots on the nail

-Low stress tolerance


-Sensitive to noise and light

-Dry skin

-Night owl, sleep disturbances

-Prone to addictions

It is also found in patients with a wide range of mental health conditions including schizophrenia, anxiety, depression and ADHD plus more.

It is theorised from clinical evidence that it is a genetic condition and can be inherited. Genetic testing can outline what anti-depressants will be tolerated in an individual according to their genetic blueprint.

Did you know that genetic testing can predict which anti-depressants will be tolerated in an individual according to their genetic blueprint ?

This is through demonstrating how different anti-depressant drugs may be tolerated in individuals with different genetic material and metabolism.

This is an example of how individual genetics and genetic testing results can influence your condition and give an explanation toward to the root cause of your health concerns.

Treatment for pyrroles

Treatment involves supplementation of nutrients that pyrroles bind to, including specific forms of magnesium, vitamin B6 and zinc (called a pyrrole primer) which is often made by compounding pharmacies.

Naturopaths & nutritionists also incorporate stress & gut support to reduce the lifelong duration of requiring a pyrrole primer.

If you'd like to know more about Pyrrole disorder, book with Monica here.

Kaptured Nutrition


McGinnis, W. R., Audhya, T., Walsh, W. J., Jackson, J. A., McLaren-Howard, J., Lewis, A., Lauda, P. H., Bibus, D. M., Jurnak, F., Lietha, R., & Hoffer, A. (2008). Discerning the Mauve Factor, Part 1. Alternative therapies in health and medicine, 14(2), 40–50.

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